The Effect of Depo-Medroxyprogesterone Acetate (DMPA) on Serum Proteins: Total Protein, Albumin and Globulin in Women

Abstract

Objectives: To determine the effect of DMPA on serum proteins: total proteins, albumin and Globulin among Nigerian women over a period of three months. Methods: This was a longitudinal cohort study of fifty consenting women in the reproductive age group who were undergoing administration of DMPA for contraception. Women received a recommended dose of 150mg of DMPA, given as deep intramuscular injection. Blood samples were collected at baseline (0), 1 and 3 months after injection. Information on the sociodemographic, obstetric, clinical characteristics, and serum levels of total proteins, albumin, IgA, IgM, and IgG was collected. Data were analysed using SPSS version 22. Results: The mean levels of IgG increased from pre-injection level of 1381.86mg% (+ 92.60mg%) to 1444.00mg% (+ 94.79mg%) at three months, p< 0.05. There was no significant change in the mean serum levels of IgA, IgM, and total proteins during three months of DMPA use. There was an increase in DBP, weight, and BMI. Conclusion: The raised mean serum levels of IgG may suggest an improved humoral immunity among women on DMPA which has potential health benefits. The increase in DBP, weight, and BMI underscore the need for proper patient selection and counseling before DMPA uptake.