The Association of Heat Stable Placental Alkaline Phosphatse with Severe Preeclampsia Among Pregnant Women at the Federal Teaching Hospital, Abakaliki, Southeast, Nigeria

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Abstract

ABSTRACT

Background:   So far, there is no accurate diagnostic or predictive investigation for pre-eclampsia. Placental alkaline phosphatase (PLAP) in preeclamptic pregnancies appears to show a trend that may be useful in prognostication. The aim of this study was to evaluate the correlation of placental alkaline phosphatase with severe preeclampsia and pregnancy outcome.

Methodology: This was a case-controlled study conducted at the Federal Teaching Hospital Abakaliki. A total of 214 pregnant women consisted of 107 women in the study group and 107 women in the control group. Each patient with preeclampsia was matched with a healthy for gestational age and parity. Data were analyzed using SPSS. Findings were presented in tables using descriptive statistics. Relationships were assessed using Pearson’s correlation and a p-value < 0.05 was statistically significant.

Results: The mean values of serum PLAP for the study and control groups were respectively 126.5IU/L and 51.1IU/l, and this was statistically significant (p-value < 0.01). The association between serum PLAP and neonatal birth weight was not statistically significant. The performance of PLAP showed a sensitivity and specificity of 80.0% and 82.0% respectively.

Conclusion: Their result showed that Serum PLAP may be a potential use as an early marker of disease onset and prognostication.